Lightsheet Microscopy

Like Confocal Microscopy, Lightsheet Microscopy enables the extraction of detailed fluorescent images from inside "thick" or whole-mount specimens.  In Lightsheet Microscopy, the sample is illuminated from the side, at right angles to the optic axis.  Samples are mounted within transparent gels or cuvettes in order to enable optical access from all sides.  This type of microscopy is faster and less phototoxic than standard laser scanning technologies.  Our LaVision Ultramicroscope II is particularly amenable to imaging large (mm-cm) cleared tissues like the intact mouse brain shown above.